miR‑519d‑3p/HIF‑2α axis increases the chemosensitivity of human cervical cancer cells to cisplatin via inactivation of PI3K/AKT signaling

Cisplatin (DDP)‑based chemotherapy is a standard treatment for cervical cancer, although resistance remains major concern. Hypoxia‑inducible factor‑2 α (HIF‑2α) plays an important role in resistance. MicroRNAs (miRs) can inhibit gene expression by binding to the 3'‑untranslated region of target gene. The authors' previous study showed that miR‑519d‑3p regulation HIF‑2α under hypoxic conditions cancer. However, function and regulatory mechanisms miR‑519d‑3p/HIF‑2α axis DDP‑resistance cancer are not fully understood. Therefore, aim present was investigate whether increased DDP regulating PI3K/AKT signaling pathway. It found lower DDP‑resistant cells (CaSki/DDP HeLa/DDP) compared with CaSki HeLa conditions. Additionally, overexpression decreased IC50 value CaSki/DDP HeLa/DDP cells, inhibited protein pathway Furthermore, it demonstrated reduced effect on cells. Moreover, results suggested also indicated suppressing